What has been your hardest to cure disease apart from cancer?

Question: What has been your hardest to cure disease apart from cancer?
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Asked by Phoenix to Michael on 9 Nov 2015. This question was also asked by jimboooooob, The Diamond Apple.
- Michael Kyriakides answered on 9 Nov 2015:
  
  @Phoenix – I haven’t cured cancer yet but hopefully i will have a positive contribution before the end of my career. I think diseases such as Parkinsons and Alzheimers are extremely difficult to cure because the brain is a very sensitive organ and we have a lot to learn about it.

Question: What has been your hardest to cure disease apart from cancer?